Norco is a prescribed painkiller that contains a mixture of Hydrocodone and Acetaminophen medication. Hydrocodone is a very potent opioid drug that relieves moderate to severe pain effectively. Whereas Acetaminophen is a lesser powerful painkiller used to enhance the effectiveness of Hydrocodone. Most of the time doctors advise their patients to buy Norco online for chronic and acute pain treatment.

Why do People Use Norco?
The Norco medication is classified as an Opioid-Analgesic. As it contains an opioid pain reliever (Hydrocodone) and a non-opioid pain reliever (Acetaminophen). Hydrocodone is known to work on certain chemicals in the brain to change how system body feels and responds to pain. Acetaminophen drug present in Norco helps to promote the effects of Hydrocodone and is also used to reduce fever.

Norco Metabolism in The System
Acetaminophen drug primarily undergoes glucuronidation and sulfate conjugation in the liver of an individual. However, a small percentage of the drug is metabolized via CYP2E1 and CYP1A2 to a hepatotoxic metabolite.

Similarly, Hydrocodone drug is metabolized in the liver to the active opioid hydromorphone via CYP2D6 also by O-demethylation, N-demethylation, and 6 ketosteroid reductions.

Hydrocodone has a half-life of 3-4 hours and that of the Acetaminophen drug is about 2-4 hours. It takes about 1-2 hours for Norco tablets to get dissolved in the bloodstream and reach their maximum effect. Norco’s effect can be observed for around 4-8 hours varying from person to person. After it is completely observed by the system, the residual Norco medicine is excreted via urine. Somewhere near 26% of Hydrocodone and, 90-100% of Acetaminophen are excreted out.

It takes several half-lives for Hydrocodone to be fully eliminated. For most individuals, Hydrocodone drug will fully clear the bloodstream within a day, but it can still be detected in the saliva, urine, or hair even after a day.

According to the studies, Hydrocodone can be detected in:

Saliva for 12 to 36 hours
Urine for up to four days
Hair for up to 90 days
Who Should Avoid Using Norco
Individuals with severe breathing irregularities.
Patients with breathing problems like sleep apnea.
People having liver and kidney diseases.
People having a seizure or head injury.
Individuals getting problems while urinating.
People who abuse street or prescription drugs and alcohol.
Individuals struggling with addiction or mental health problems.
Patients with thyroid, pancreas, or gallbladder problems.
An individual having significant respiratory depression.
Anyone having acute or severe bronchial asthma.
Patients known or suspected of having gastrointestinal obstruction, including paralytic ileus.
People who are hypersensitive to Hydrocodone or Acetaminophen drugs.
Prolonged use of Norco medicine during pregnancy can cause severe withdrawal symptoms in the newborn infant that could be life-threatening. So it is better to avoid Norco tablets during Pregnancy.
Hydrocodone bitartrate and Acetaminophen can pass into breast milk and may harm your baby. Hence, nursing mothers should stop using Norco.
Norco Dosage
Generally, the dosage on Norco is based on an individual’s medical conditions and response to treatment using the medicine. In children, the dosage is based on their corresponding weights. However, it is not recommended for children or infants below the age of 2 years.

Avoid taking an increased dose, taking the medication more frequently, or taking it for a longer period other than prescribed. Properly taper and discontinue the Norco medication as directed by the concerned doctor. Always buy Norco online in exact doses as prescribed to avoid any kind of overdose situation.

Adult Dosage
1 or 2 capsules of Norco should be taken every 4 to 6 hours in a day as prescribed. Your doctor may further increase your dose as needed after observing Norco’s effects on your system. Whatsoever, the dose of Norco must not exceed 8 capsules or 60 mg per day.

Available Doses
Norco 5-325 mg
Norco 7.5-325 mg
Norco 10-325 mg
Overdose
There are a host of symptoms and signs that can emerge when a person overdoses on Norco medication. Some of the more common symptoms of a Hydrocodone overdose include but are not limited to:

Constricted pupils
Nausea
Vomiting
Abdominal spasms
Constipation
Drowsiness
Coma
Seizures
Weak pulse
Low blood pressure
Shallow breathing
Trouble while breathing
Constipation
Drowsiness
Low blood pressure
Adverse Effects on Long-Run Use
Biliary tract spasm
Hallucinations
Circulatory collapse
Excessive histamine release
Physical and psychological dependence
Bradycardia
Cardiac arrest
Confusion
Dizziness
Severe drowsiness
Dyspnea
Fatigue
Hypotension
Coma
Dysphoria
Euphoria
Lethargy
Lightheadedness
Frequent mood swings
Stupor
Nausea
Vomiting
Weakness
Peptic ulcer
Agranulocytosis
Hemolytic anemia
Hepatic necrosis
Major respiratory depression, etc.
These are a few of the common and fatal adverse effects induced by the long-term use of Norco medicine. Sometimes these symptoms can lead to fatal consequences. In order to stay safe from these symptoms always make sure to buy Norco online to get legal and legit medications on time.

Interaction With Other Substances
Avoid other Acetaminophen-containing drugs
Not recommended with benzodiazepines or other CNS depressants drugs
Alcohol and other opioids products
Norco is not recommended to be used during or within 14 days of using MAOIs
Risk of serotonin syndrome with serotonergic drugs (e.g, SSRIs, SNRIs, TCAs, triptans, 5-HT3 antagonists, Mirtazapine, Trazodone, Tramadol, MAOIs, Linezolid, IV Methylene blue)
Avoid concomitant mixed agonist or antagonist opioids such as butorphanol, nalbuphine, pentazocine, or partial agonist like buprenorphine
Potentiated by CYP3A4 inhibitors (eg, macrolides, azole antifungals, protease inhibitors)
Opioid pain medicines like Oxycodone, Hydrocodone, etc.
Avoid using sedatives like Valium, Alprazolam, Lorazepam, Xanax, Klonopin, Diazepam, etc.
Sleeping pills, muscle relaxers, and medicine to treat mood disorders or mental illness are prohibited with Norco
Abuse and Misuse of Norco Medicine
Norco is categorized as a Schedule II drug under the Controlled Substances Act. Schedule II drugs generally have a medically accepted use and less abuse potential than Schedule I drugs. Despite this, many Schedule II drugs are often abused for their euphoric effects.

Any time an individual uses Norco tablets without a prescription or buys Norco online or from the nearest medical store other than what is prescribed, it is considered abuse. Continuous abuse of Norco medicines can lead to physical dependence or opioid addiction. This is characterized by a tolerance to the drug and withdrawal symptoms caused while discontinuing. Some of the side effects induced after abusing or misusing Norco tablets:

Seizures
Depression
Fear
Dizziness
Ringing sound in the ears
Nausea
Vomiting
Headaches
Confusion
Blurry vision
To avoid any such dangerous drug abuse symptoms, doctors support and promote buying Norco with a prescription. An individual should buy the doses responsibility. Anyhow you should always buy Norco online for the exact dose without failing.

Norco Drug Addiction
If you find an individual taking Norco medicine for longer than prescribed or taking it in larger doses despite its negative consequences, the individual may have an addiction. Your doctor may have to reduce your Norco dose slowly rather than stopping it suddenly. Any abrupt discontinuation will induce withdrawal symptoms.

Needing more Norco to achieve the same effects and relief
Mixing Norco with other drugs for a better high effect
Doctor shopping to get Norco drug
Spending a lot of time getting or using Norco
Disavowing responsibilities and relationships
Norco’s Discontinuation Effects
Do not abruptly discontinue Norco tablets in a patient physically dependent on opioids. When discontinuing Norco medication in a physically dependent patient, gradually tapering the dosage is highly recommended. Rapid tapering of Norco pills for an individual physically dependent on opioids may lead to a withdrawal syndrome and return of pain.

Anxiety
Restlessness
Runny nose
Muscle aches
Agitation
Insomnia
Excessive sweating